Ambroxol Hydrochloride and Cetirizine Hydrochloride are often prescribed together for greater patient acceptability, increased potency, multiple activity, fewer side effects and quick relief. Ambroxol Hydrochloride and Cetirizine Hydrochloride are used for the treatment of bronchitis, cough, and allergy. Conventional Ambroxol and Cetirizine tablet available in the market are not suitable in certain cases such as motion sickness, sudden episodes of allergic attacks, or coughing and when drinking water is not available. Particularly these types of difficulty are faced by pediatric and geriatric patients. An attempt has been made to develop and enhance the stability of two combine drugs Ambroxol Hydrochloride and Cetirizine Hydrochloride, we prepared fast disintegration tablets. Total six formulations (F1–F6) were prepared to study the effect of superdisintegrants shown in Table I. Tablets were prepared by the technique of direct compression methods. Required quantity of each ingredient was taken for each specified formulation. The superdisintegrant, sodium starch glycolate (1%, 2%, 4%, 6%, 8%, and 10%) concentration was used to develop the tablets. All the ingredients were passed through mesh size # 60. All the ingredients were cogrind in a pestle motor. Finally talc and Sodium Stearyl fumarate were added and mixed for 5 minutes. The blended excipients were compressed into tablets using tablet compression machine (Madhur Industries, India). The dissolution studied results revealed that in both of the drug Ambroxol Hydrochloride and cetirizine hydrochloride in phosphate buffer pH 6.8 and pH 7.4 dissolution medium were shown within the specified Pharmacopoeias limit.
ambroxyol hydrochloride; Cetirizine hydrochloride; cough; allergy; stability enhancement
International Journal of Trend in Scientific Research and Development - IJTSRD having
online ISSN 2456-6470. IJTSRD is a leading Open Access, Peer-Reviewed International
Journal which provides rapid publication of your research articles and aims to promote
the theory and practice along with knowledge sharing between researchers, developers,
engineers, students, and practitioners working in and around the world in many areas
like Sciences, Technology, Innovation, Engineering, Agriculture, Management and
many more and it is recommended by all Universities, review articles and short communications
in all subjects. IJTSRD running an International Journal who are proving quality
publication of peer reviewed and refereed international journals from diverse fields
that emphasizes new research, development and their applications. IJTSRD provides
an online access to exchange your research work, technical notes & surveying results
among professionals throughout the world in e-journals. IJTSRD is a fastest growing
and dynamic professional organization. The aim of this organization is to provide
access not only to world class research resources, but through its professionals
aim to bring in a significant transformation in the real of open access journals
and online publishing.